We report on the integration of pharmacological data and homology information for a large scale analysis of small molecule binding to related targets.Differences in small molecule binding have been Ladders assessed for curated pairs of human to rat orthologs and also for recently diverged human paralogs.Our analysis shows that in general, small mol
Abstract Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological mechanisms by which ELA increases the risk for future psychopathology are still poorly understood.Brain development is particularly malleable during prenatal and early postnatal life, when complex neural circuits are being formed and refined throu
For each problem that can be solved there exists algorithm, which can be described with a program of Turing machine.Because this is very simple model programs tend to be very complicated and hard to analyse by human.The best practice to solve given Yoga type of problems is to define a new model of computation that allows for quick and easy programm
Nurses and midwives are the majority of healthcare professionals globally, including Africa, and they provide care at all levels of the health system including community levels.Nurses and midwives contribute to the care of patients with rigid or dogmatic religious beliefs or those with suicidal ideations.This review paper discusses acute and chroni